08 Januar 2019 - POSTDOC

Post-doc (m/f): Production of Monoclonal Antibodies using Humanized Mice

Employer: Medizinische Hochschule Hannover
Country: Germany
City: Hannover

The Hannover Medical School,
Clinic of Hematology, Homeostasis, Oncology
and Stem Cell Transplantation offers a position as

Post-doc (m/f): Production of Monoclonal Antibodies using Humanized Mice

This position of the Regenerative Immune Therapies Applied Laboratory within the Excellence Cluster REBIRTH is financed by the Deutsches Zentrum für Infektionsforschung/ Centre for Infections Research (DZIF). The research will be conducted in collaboration with the Helmholtz Zentrum München Research Unit Gene Vectors. The translational project is headed by a consortium with expertise in Epstein Barr Virus (EBV) and human Cytomegalovirus (HCMV). The consortium will create novel fully human neutralizing monoclonal antibodies aimed to improve the survival of immune compromised patients with EBV or HCMV reactivations.

For further information, please visit the following links:
www.stripecke-mhh.de
http://www.rebirth-hannover.de/research/research-groups/area-b1-disease-models/unit-64.html
http://www.dzif.de/forschung/infektionen_im_immungeschwaechten_wirt/

The post-doc position is available on 01.01.2019 and funded for two years.
Deadline for applications is the 31.03.2019.

Candidate´s task:
The post-doc’s task is to generate viral vectors constructs and different vaccines to immunize mice reconstituted with a human immune system. This system will be further optimized for the generation and identification of human antibodies reactive against EBV and HCMV. The selected human neutralizing monoclonal antibodies will be characterized, enhanced and recombinantly expressed in cell culture for future clinical use. The post-doc will co-lead and participate in experiments with the team members and co-manage the services provided by consortium partners in order to reach the defined targets within the calculated time and budget. The post-doc will report to the consortium partners and write reports and documentations for the funding agency (DZIF).

Qualifications:
PhD or MD/PhD title obtained within last 5 years, qualified for experiments with mice (FELASA B certificate), team leading skills and strong publication record. Candidates should have demonstrated solid previous experience with: mouse handling (human hematopoietic stem cell transfer, virus infections, immunizations, collection of tissues, optical imaging analyses, histology), immunologic analyses (multicolor flow cytometry for characterization of human T and B cells, B cell immortalization, IgG ELISA, antibody neutralization assays), molecular biology (lentiviral vector construction and production, single cell RNA sequencing), bioinformatics (BCR analyses in silico). Excellent organizational skills, initiative, responsibility, team-work, fluency (verbal and written) in English and German, experience in writing animal study protocols, computer skills for data analyses and presentation and reports (MS Word, Excel, Powerpoint, Adobe Acrobat, GraphPad Prism, SAP).

Compensation:
The salary will be based on the university pay scheme for researchers (m/f) and will be dependent on personal qualification (up to 100 % TV-L 13 – 38,5 hours per week). The Hannover Medical School is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.

If you are interested in applying, send per email a cover letter explaining your motivation, CV, certificates and names of 3 persons able to provide reference letters to:

Prof. Dr. Renata Stripecke stripecke.lab@mh-hannover.de

Please do not send paper applications with original documents.

Hannover Medical School
Klinik für Hämatologie, Hämostaseologie,
Onkologie und Stammzelltransplantation, OE 6862
Prof. Dr. Renata Stripecke
Carl-Neuberg-Str. 1
30625 Hannover
Germany
Telefon +49 511 532 6999
stripecke.lab@mh-hannover.de



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