Short description

Vector vaccines are genetically modified (and therefore harmless) viruses that serve as vectors for inserting the genetic material of a pathogen into target cells. The introduced DNA sequence can imitate an infection and trigger the production of antibodies.

Detailed description

In the DZIF a vector vaccine based on the "Modified Vaccinia Ankara" virus (MVA) is being developed. This MVA virus was generated at the LMU as a vaccine against smallpox more than 30 years ago. The scientists selected the spike protein on the surface of the SARS-CoV-2 virus as the appropriate coronavirus component. The resulting vaccine virus then penetrates the cells as due to the vaccination and synthesises the spike protein, which is recognised by the immune system as "foreign" and thus stimulates the immune response.