Heidelberg University Hospital

Nucleoside Booster Project: Broad-spectrum antivirals for pandemic preparedness

The SARS-CoV-2 pandemic and other epidemics in recent decades have highlighted the need to develop effective measures to combat emerging infectious diseases in a timely manner. For most emerging viral pathogens, no vaccines or antiviral drugs are yet available. Since it is difficult to predict which ...

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Preclinical development of Amidochelocardins

The challenge of antibiotic drug development today is the discovery and optimisation of novel bioactive compounds that do not show cross-resistances with clinically applied antibiotics, ideally due to a novel mode of action (MoA) which adresses unexploited microbial targets. In the case of ...

University of Cologne

R-Net: Core network for the study of multidrug-resistant bacterial organisms

Implementation of evidence-based infection control practices to reduce healthcare associated infection remains a national and international priority. R-Net investigates the effect of various interventions aimed at limiting the spread of infections due to multi-drug resistant organisms (MDRO) ...

Ludwig-Maximilians-Universität München

Reduction and elimination of HIV reservoirs

The development of potent antiretroviral treatment (ART) strategies has significantly changed the face of the HIV/AIDS pandemic from a lethal disease to a chronic livable condition for infected individuals with access to care. However, in spite of ground-breaking advances in anti-HIV treatment, cure ...

University of Cologne

The impact of colonization with MDRO in complex surgical patients (TIARA)

Major abdominal surgery in particular is associated with high postoperative infection rates. Despite well-established surveillance systems for surgical wound infections, there is a lack of comprehensive reporting on infectious complications and the impact of the use of anti-infectives during and ...

University Hospital Tübingen

Vaccine development for blood-stage malaria

Each year, over 200 million people worldwide contract malaria. The malaria pathogens, called plasmodia, are transmitted by mosquitoes and pass through different stages of development in the liver and red blood cells. Humans develop immunity against the disease after having been routinely exposed to ...