Healthcare-associated and Antibiotic-resistant bacterial Infections
A phenomenal increase in infections caused by Antibiotic-resistant bacterial pathogens has become one of the biggest public health concerns over the last ten years. Most severe cases result from healthcare-associated bacterial infections, which are increasingly caused by methicillin-resistant Staphylococcus aureus and extended-spectrum beta lactamase (ESBL)-producing enterobacteria. Unfortunately, most pharmaceutical companies have shifted their R&D activities towards chronic infections and diseases, and only very few new compounds are expected to become available in the next decade. The Thematic Translational Unit Healthcare-Associated and Antibiotic-Resistant Bacterial Infections will support translational research to develop novel anti-infective strategies. It will also foster the establishment of clinical studies to assess the suitability of improved infection control measures and appropriate use of antibiotics (e.g. antibiotic stewardship) for reducing the burden of healthcare-associated and antibiotic-resistant bacterial infections.
- Evaluation of programs for limiting the use of broad-spectrum antimicrobials (antibiotic stewardship programs; faster molecular diagnostics)
- Controlling the spread of multi-resistant bacteria by effective hygiene management (patient screening and isolation; pathogen epidemiology)
- Development of new vaccines and drugs (new decolonization strategies, virulence blockers)
Participating Focus Sites
External partners: Institute for Microbiology and Hygiene of the University Hospital Freiburg, Charité Berlin, Medical Microbiology Münster, Curetis AG (Holzgerlingen) and Hyglos GmbH (Bernried)