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Prof. Dr. Ralph Holl

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Ralph Holl

Prof. Dr. Ralph Holl

Telefonnummer +49 40 42838 2825
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Partner Site
Hamburg - Lübeck - Borstel - Riems
Institution
University of Hamburg
Research Area
Novel Antibiotics

Research of the employee

Working Groups Projects
Hamburg - Lübeck - Borstel - Riems

Medicinal chemistry of novel anti-infectives

Medicinal chemistry, also termed medical chemistry, researches chemical properties of new and old agents and develops innovative therapy options. Ralph Holl’s research group focuses on manufacturing and/or designing new inhibitors: small molecules that specifically target metabolic pathways in bacteria and consequently act as antibiotics. Meanwhile, a large number of 3D [...]

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Bonn - Köln | Hamburg - Lübeck - Borstel - Riems | Hannover - Braunschweig | Tübingen

PAFAP—Pseudomonas aeruginosa-focused anti-infectives pipeline

In the current WHO list of bacterial priority pathogens (WHO BPPL 2024), the World Health Organisation classifies carbapenem-resistant Pseudomonas aeruginosa bacteria as a high-priority pathogen, which means there is an urgent need for new anti-infectives to combat this problematic bacterium. To address this need, the PAFAP project has brought together a [...]

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Publications of the employee

Sep 2024
J Med Chem

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Autoren
Mielniczuk S et al.
Go to publication
Jan 2023
Bioorg Chem

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Autoren
Wimmer S et al.
Go to publication
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German Centers for Health Research
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