Leibniz Institute for Experimental Virology (HPI)

An integrated approach for HIV-cure "Shock and Kill" strategies

The development of new therapeutic approaches is still a major challenge in the treatment of HIV-1 infected patients. Part of the problem arises primarily from the virus' ability to latency: the virus hides in the genetic material of the cells and in this way becomes "invisible" to the immune system ...

University of Tübingen

BLOOMY-PREDICT – Bloodstream infections due to multidrug-resistant organisms

Bloodstream infections (BSI) are associated with high morbidity and mortality worldwide and are still considered as one of the most severe bacterial infections. The BLOOMY-PREDICT project is an observational study, which runs at five German university hospitals. Within the scope of the project ...

University of Bonn

Corallopyronin - A development through to phase I trial

More than 21 million people in Africa are infected with the threadworm Onchocerca volvulus, the pathogen causing river blindness. About one in ten of those affected goes blind. What is needed are active agents that kill the long-lived adult worms. With Corallopyronin A, DZIF scientists have found an ...

University Hospital Tübingen

Development of a vaccine to prevent malaria in African children

Malaria continues to account for approximately half a million deaths each year. Children in highly endemic regions in Africa are the most severely affected. To date, an effective vaccine against malaria does not exist. In Tübingen, a vaccination approach which leads to full immunity against malaria ...

Technical University of Munich

Enabling adoptive T cell transfer from seronegative individuals

Temporary loss of T cell immunity towards various virus infections (e.g. Cytomegalovirus (CMV), Epstein Barr Virus (EBV) or Adenovirus (AdV)) is a main cause of infection-related mortality in severely immunocompromised patients, like individuals upon allogeneic hematopoetic stem cell transplantation ...

Hannover Medical School

Immune-regulation of human cytomegalovirus in the immunocompromised host

Hematological stem cell transplantation (HSCT) is one of the most important treatments for haematological malignancies. Two major complications after stem cell transplantations are the development of graft-versus-host disease (GvHD) and the reactivation of the human cytomegalovirus (HCMV), which ...

University of Tübingen

New anti-virulence drugs against S. aureus

In this project, the scientists have developed a monoclonal antibody directed against a resistance protein that is crucial for the virulence, i.e. infectious effect, of Staphylococcus aureus. The monoclonal antibody can restore the body's own defence and thus make the bacteria vulnerable to ...

University Hospital Tübingen

New strategies for specific eradication of Staphylococcus aureus

In this project, the scientists develop genetically engineered phage lysins and specific bacteriocins for the elimination of hospital germs such as Staphylococcus aureus, they clarify mechanisms of potential resistance mechanisms, and they analyse whether broad-spectrum or specifically acting agents ...