University of Tübingen

BLOOMY-PREDICT – Bloodstream infections due to multidrug-resistant organisms

Bloodstream infections (BSI) are associated with high morbidity and mortality worldwide and are still considered as one of the most severe bacterial infections. The BLOOMY-PREDICT project is an observational study, which runs at five German university hospitals. Within the scope of the project ...

Hannover Medical School

Clinical cohorts for HIV remission

The project “Clinical cohorts for HIV remission” will continue and expand ongoing research around the treatment of primary HIV infection (TopHIV) Cohort of patients with acute HIV infection. Beyond studies about their immune responses and reservoir formation, selected TopHIV individuals will be ...

University of Bonn

Corallopyronin - A development through to phase I trial

More than 21 million people in Africa are infected with the threadworm Onchocerca volvulus, the pathogen causing river blindness. About one in ten of those affected goes blind. What is needed are active agents that kill the long-lived adult worms. With Corallopyronin A, DZIF scientists have found an ...

Technical University of Munich

Development of a new prophylactic vaccine against Helicobacter pylori

Helicobacter pylori is one of the top 10 bacterial threats listed by the WHO, for which treatment is becoming increasingly difficult due to rising antibiotic resistance. More than half of the world's population is chronically infected with this bacterium. H. pylori is a recognised class I carcinogen ...

University Hospital Tübingen

Development of a vaccine to prevent malaria in African children

Malaria continues to account for approximately half a million deaths each year. Children in highly endemic regions in Africa are the most severely affected. To date, an effective vaccine against malaria does not exist. In Tübingen, a vaccination approach which leads to full immunity against malaria ...

Technical University of Munich

Enabling adoptive T cell transfer from seronegative individuals

Temporary loss of T cell immunity towards various virus infections (e.g. Cytomegalovirus (CMV), Epstein Barr Virus (EBV) or Adenovirus (AdV)) is a main cause of infection-related mortality in severely immunocompromised patients, like individuals upon allogeneic hematopoetic stem cell transplantation ...