Projects

Children as well as HIV-positive adults often suffer from extrapulmonary tuberculosis (TB). Due to the low sensitivity of routine microbiological TB tests, it is often difficult to obtain confirmation of mycobacterial disease. Point-of-care ultrasound (POC-US) is becoming increasingly established as ...

Recent studies show that there has been an increasing spread of vancomycin-resistant enterococci (VRE) in hospital patients in Germany in recent years. Enterococci are abundant in the intestines of humans (and animals) and are generally only slightly pathogenic. However, infections caused by these ...

Bloodstream infections (BSI) are associated with high morbidity and mortality worldwide and are still considered as one of the most severe bacterial infections. The BLOOMY-PREDICT project is an observational study, which runs at five German university hospitals. Within the scope of the project ...

The project “Clinical cohorts for HIV remission” will continue and expand ongoing research around the treatment of primary HIV infection (TopHIV) Cohort of patients with acute HIV infection. Beyond studies about their immune responses and reservoir formation, selected TopHIV individuals will be ...

More than 21 million people in Africa are infected with the threadworm Onchocerca volvulus, the pathogen causing river blindness. About one in ten of those affected goes blind. What is needed are active agents that kill the long-lived adult worms. With Corallopyronin A, DZIF scientists have found an ...

By applying innovative diagnostic methods such as rapid point-of-care tests, multi-omics technologies as well as novel predictive models, clinical management and thus most likely treatment outcomes can be improved. In addition to the high information content of these new methods, the prompt ...

Helicobacter pylori is one of the top 10 bacterial threats listed by the WHO, for which treatment is becoming increasingly difficult due to rising antibiotic resistance. More than half of the world's population is chronically infected with this bacterium. H. pylori is a recognised class I carcinogen ...

Malaria continues to account for approximately half a million deaths each year. Children in highly endemic regions in Africa are the most severely affected. To date, an effective vaccine against malaria does not exist. In Tübingen, a vaccination approach which leads to full immunity against malaria ...

Gram-negative bacteria are naturally insensitive to many antibiotics due to their additional outer membrane. In addition, the bacteria have acquired resistance to clinically used antibiotics in recent decades, resulting in multidrug-resistant bacteria. Novel classes of antibiotics are needed to ...

Advanced chronic kidney disease (CKD) is among the most common chronic health conditions in Germany. CKD 5D patients (CKD stage five with indication for dialysis) have a weakened immune system and are highly susceptible to infections. Pneumococcal pneumonia is one of the most frequent causes of ...