Projects

In the current WHO list of bacterial priority pathogens (WHO BPPL 2024), the World Health Organisation classifies carbapenem-resistant Pseudomonas aeruginosa bacteria as a high-priority pathogen, which means there is an urgent need for new anti-infectives to combat this problematic bacterium. To ...

Pseudomonas aeruginosa is a bacterial pathogen that can cause life-threatening infections, such as sepsis and pneumonia. One of the key weapons used by this bacterium is the type III secretion system (T3SS), which contains the protein PcrV. Researchers at the DZIF discovered that chronically ...

The previous R-Net projects (R-Net 1.0 and 2.0) provided important insights into the prevalence of multidrug-resistant organisms (MDROs) through cross-sectional studies. However, the longitudinal development of colonization and the factors influencing its acquisition, persistence, and transmission ...

Implementation of evidence-based infection control practices to reduce healthcare-associated infection remains a national and international priority. R-Net investigates the effect of various interventions aimed at limiting the spread of infections due to multi-drug resistant organisms (MDRO) ...

The development of potent antiretroviral treatment (ART) strategies has significantly changed the face of the HIV/AIDS pandemic from a lethal disease to a chronic livable condition for infected individuals with access to care. However, in spite of ground-breaking advances in anti-HIV treatment, cure ...

With ten million cases and 1.4 million deaths in 2021 alone, Mycobacterium tuberculosis remains one of the world's most dangerous pathogens. Early diagnosis of the disease and tracking of people at increased risk of developing TB are critical to minimising infection and containing TB. The ongoing ...

Infections caused by multidrug-resistant Gram-negative organisms are a major contributor to severe disease and mortality worldwide. Infection is often preceded by colonization of the intestine with these organisms, which cannot be controlled by oral antibiotic therapy. Fecal Microbiota Transfer (FMT ...

Postoperative infections following major abdominal surgery remain common and difficult to predict. A key reason is the incomplete understanding of how individual differences in the gut microbiome, host immunity, and microbial metabolites shape infection susceptibility. Following completion of ...

Major abdominal surgery in particular is associated with high postoperative infection rates. Despite well-established surveillance systems for surgical wound infections, there is a lack of comprehensive reporting on infectious complications and the impact of the use of anti-infectives during and ...

Acute hepatitis is usually caused by known (hepatitis) viruses, toxic substances, or autoimmune diseases. In about 10-20 percent of cases of acute hepatitis, however, no such cause can be found. Many of these cases show laboratory or histologic evidence of a viral etiology, but the known viruses ...