PANTIPA: Preclinical development of patient-derived monoclonal antibodies targeting Pseudomonas aeruginosa

By applying innovative diagnostic methods such as rapid point-of-care tests, multi-omics technologies as well as novel predictive models, clinical management and thus most likely treatment outcomes can be improved. In addition to the high information content of these new methods, the prompt availability of the results as well as the [...]

Recent studies show that there has been an increasing spread of vancomycin-resistant enterococci (VRE) in hospital patients in Germany in recent years. Enterococci are abundant in the intestines of humans (and animals) and are generally only slightly pathogenic. However, infections caused by these resistant pathogens pose an immediate threat to [...]

Bloodstream infections (BSI) are associated with high morbidity and mortality worldwide and are still considered as one of the most severe bacterial infections. The BLOOMY-PREDICT project is an observational study, which runs at five German university hospitals. Within the scope of the project, different clinical values of patients such as [...]

The progressing global spread of antibiotic-resistant bacteria, particularly Klebsiella pneumoniae and Escherichia coli, poses a massive threat to public health as traditional antibiotics lose their effectiveness. Often, the actual infection is preceded by the asymptomatic colonization of the gut with these resistant bacteria. In cases of immune deficiency, these [...]

Antibiotic resistance is increasing at an alarming rate worldwide. New treatment options are urgently needed. Due to their specificity toward bacterial hosts, bacteriophages are a promising alternative or adjunct therapeutic option to conventional antibiotics. Their specificity and lack of adverse side effects make phages important objects in biomedicine research. Among [...]

In many infections, even proper antibiotic treatment does not lead to the expected therapeutic success. In the case of treatment with antibiotics, the doctor usually first decides which antibiotic to prescribe based on the type of infection. If resistance to the antibiotic already prescribed is detected, the therapy will be [...]

There are a number of factors responsible for the development of antibiotic resistance. So far, the interactions between pathogens and the complex microbial colonisation (microbiota) of the human body under the selection pressure of antibiotic treatment play a little studied and underestimated role. DZIF-coordinated study cohorts such as TIARA make [...]

In this project, the scientists develop genetically engineered phage lysins and specific bacteriocins for the elimination of hospital germs such as Staphylococcus aureus, they clarify mechanisms of potential resistance mechanisms, and they analyse whether broad-spectrum or specifically acting agents have a more effective and lasting effect on colonization by [...]

The bacterial pathogens Chlamydia trachomatis and Neisseria gonorrhoeae are the most common sexually transmitted infections (STIs) leading to infertility in women. The World Health Organisation (WHO) estimates that 89 million new infections with genital chlamydia and 78 million infections with gonococci occur worldwide every year. In contrast to other European [...]

The previous R-Net projects (R-Net 1.0 and 2.0) provided important insights into the prevalence of multidrug-resistant organisms (MDROs) through cross-sectional studies. However, the longitudinal development of colonization and the factors influencing its acquisition, persistence, and transmission remain poorly understood. The third project phase, R-Net SHIELD, addresses this knowledge gap by [...]

Implementation of evidence-based infection control practices to reduce healthcare-associated infection remains a national and international priority. R-Net investigates the effect of various interventions aimed at limiting the spread of infections due to multi-drug resistant organisms (MDRO)—including infection prevention and control, decolonisation, antimicrobial stewardship (AMS) and the development of new antimicrobials [...]

Infections caused by multidrug-resistant Gram-negative organisms are a major contributor to severe disease and mortality worldwide. Infection is often preceded by colonization of the intestine with these organisms, which cannot be controlled by oral antibiotic therapy. Fecal Microbiota Transfer (FMT) is a promising alternative for achieving long-term decolonization of the [...]

Postoperative infections following major abdominal surgery remain common and difficult to predict. A key reason is the incomplete understanding of how individual differences in the gut microbiome, host immunity, and microbial metabolites shape infection susceptibility. Following completion of patient enrollment in the TIARA cohort study, "TIARA-IMPACT" conducts in-depth analyses of [...]

Major abdominal surgery in particular is associated with high postoperative infection rates. Despite well-established surveillance systems for surgical wound infections, there is a lack of comprehensive reporting on infectious complications and the impact of the use of anti-infectives during and after surgery. The TIARA project aims to close this knowledge [...]

Patients colonized with vancomycin-resistant enterococci (VRE)—particularly immunocompromised patients—are at increased risk of developing subsequent VRE infections. Repeated antibiotic therapies are not an option for decolonization in patients receiving immunosuppressive therapy, as antibiotic-induced selection pressure may promote the further spread of multidrug-resistant enterococci. Effective and sustainable strategies for reducing or eradicating [...]

Enterococcus faecium is intrinsically resistant to many antibiotics and can cause difficult-to-treat infections, especially in immunocompromised and other vulnerable patients. Vancomycin-resistant E. faecium (VRE) strains are especially problematic because vancomycin cannot be used to treat these infections. Resistance is mediated by the VanA or VanB enzyme complexes, which neutralize the [...]