Sepsis develops as a result of an infection when the immune response harms the body’s own tissues and organs. Without intensive care, sepsis is often fatal.
Originating from a local inflammation such as a wound or pneumonia, pathogens or their toxins spread in the body and activate the entire immune system
. A key role plays lipopolysaccharide, which is found in the membrane of gram-negative
bacteria. The over-activated immune system floods the body with messenger substances. Possible consequences are a multitude of inflammatory reactions, shock, multi-organ failure and death. The immediate administration of antibiotics as well as the maintenance of the blood circulation is pivotal. Sepsis is the third most common illness-related cause of death in Germany.