Infections caused by Gram-negative multidrug-resistant organisms are one of the leading causes of morbidity and mortality worldwide. Infection is often preceded by colonization of the intestine with these organisms, which cannot be controlled by oral antibiotic therapy. Fecal microbiota transplantation (FMT) is a promising alternative for achieving long-term decolonization of [...]

The progressing global spread of antibiotic-resistant bacteria, particularly Klebsiella pneumoniae and Escherichia coli, poses a massive threat to public health as traditional antibiotics lose their effectiveness. Often, the actual infection is preceded by the asymptomatic colonization of the gut with these resistant bacteria. In cases of immune deficiency, these [...]

Antibiotic resistance is increasing at an alarming rate worldwide. New treatment options are urgently needed. Due to their specificity toward bacterial hosts, bacteriophages are a promising alternative or adjunct therapeutic option to conventional antibiotics. Their specificity and lack of adverse side effects make phages important objects in biomedicine research. Among [...]