Genome Mining | German Center for Infection Research

Short description

Genome mining refers to the targeted search of genomic data for genes or gene clusters that provide clues about specific biological properties or potential bioactive compounds.

Detailed description

In bacteria, for example, genome mining is used to identify so-called biosynthetic gene clusters. These contain the genetic information for the production of certain natural products, including substances of potential medical interest.
Using bioinformatics methods, such gene clusters can be predicted within the genome and investigated in a targeted manner. This approach also makes it possible to detect natural products that are produced only in small quantities, or not at all, under standard laboratory conditions and are therefore difficult to discover using conventional methods.

Dec 2025

RSC Chem Biol

Expanding the actinomycetes landscape for phosphonate natural products through genome mining

Autoren

Zimmermann A et al.

Person in protective gear walking along a hallway

Improving the treatment of Lassa fever—first clinical trial with favipiravir shows promising results

Although the infectious disease Lassa fever can be fatal, there is a lack of treatment options with proven efficacy. Researchers at the Bernhard Nocht Institute for Tropical Medicine (BNITM) and the

Jun 2025

J Nat Prod

Genome Mining Leads to the Discovery of Kasichelins A-D, Unusual β-Alanine- and β-Aminoisobutyric Acid-Containing Siderophores from Streptomyces

Autoren

Bader M et al.

Nov 2024

Microb Biotechnol

Integrated genome and metabolome mining unveiled structure and biosynthesis of novel lipopeptides from a deep-sea Rhodococcus

Autoren

Ragozzino C et al.

May 2023

Nucleic Acids Res

FunARTS, the Fungal bioActive compound Resistant Target Seeker, an exploration engine for target-directed genome mining in fungi

Autoren

Yılmaz TM et al.

Universität zu Lübeck

MiFactR: Microbiota- and treatment-derived determinants of antibiotic resistance

There are a number of factors responsible for the development of antibiotic resistance. So far, the interactions between pathogens and the complex microbial colonisation (microbiota) of the human body under the selection pressure of antibiotic treatment play a little studied and underestimated role ...

Targeted test for antibiotic resistance in clinical Enterobacter species

Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide. Some of their representatives are highly resistant to commonly used antibiotics

Dec 2017

ACS Chem biol

Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach

Autoren

Surup F et al.

Mar 2022

J Nat Prod

Genome-Mining-Guided Discovery and Characterization of the PKS-NRPS-Hybrid Polyoxyperuin Produced by a Marine-Derived Streptomycete

Autoren

Kresna IDM et al.

Visualisation of luminous strands of DNA as well as of a ring that depicts the combined analysis of many different bacterial genomes.

Only three percent of potential bacterial drug sources known

The emergence of antibiotic-resistant pathogens and the increasing difficulty in developing new drugs has contributed to global challenges in combating infectious diseases. An extensive bioinformatics