Short description

A granuloma is a well-defined accumulation of immune cells that forms in tissue as part of a prolonged inflammatory response.

Detailed description

Granulomas develop when the immune system is unable to completely eliminate certain pathogens, foreign substances, or other inflammatory stimuli. In particular, specialized phagocytes (macrophages) and other immune cells accumulate and form a characteristic tissue structure.

Granulomas occur in various infectious and non-infectious diseases. A well-known example is tuberculosis, in which granulomas develop in response to Mycobacterium tuberculosis.