Amidochelocardin | German Center for Infection Research

Short description

Amidochelocardin is a broad-spectrum antibiotic.

Detailed description

DZIF scientists developed amidochelocardin by rational genetic engineering of the natural compound chelocardin. The antibiotic is effective against multiresistant bacteria, which are often responsible for hospital-acquired infections.

Jul 2024

ACS Pharmacol Transl Sci

Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters

Autoren

Rox K et al.

Dec 2023

Microbiol Spectr

Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models

Autoren

Rox K et al.

Jul 2023

Angew Chem Int Edit

Revision of the Absolute Configurations of Chelocardin and Amidochelocardin

Autoren

Sikandar A et al.

Aug 2022

mSphere

Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress

Autoren

Brauer M et al.

Sep 2020

Antibiotics (Basel)

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Autoren

Hennessen F et al.

Feb 2020

Eur J Med Chem

Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics

Autoren

Grandclaudon C et al.

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Preclinical development of Amidochelocardins

The challenge of antibiotic drug development today is the discovery and optimisation of novel bioactive compounds that do not show cross-resistances with clinically applied antibiotics, ideally due to a novel mode of action (MoA) which adresses unexploited microbial targets. In the case of ...