Animal model | German Center for Infection Research

Short description

An animal model is a non-human animal species used in biomedical research because it can mimic aspects of a biological process or disease that occur in humans.

Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Preclinical development of Amidochelocardins

The challenge of antibiotic drug development today is the discovery and optimisation of novel bioactive compounds that do not show cross-resistances with clinically applied antibiotics, ideally due to a novel mode of action (MoA) which adresses unexploited microbial targets. In the case of ...

Two tick species sharing a leave: Ixodes ricinus in the front. (Please use this picture only in connection to the press release).

Scientists warn: 2018 will be the ‘year of the tick’

This summer there will be a particularly large amount of ticks and thus a higher risk of getting meningitis or Lyme disease (borreliosis), because these diseases are transmitted by ticks. Scientists

Tuberculosis bacteria: (left) treated with BTZ043 holes develop in the mycobacterial cell walls; (right) untreated

Tuberculosis: clinical trials on a newly developed drug initiated

The first antibiotic against tuberculosis that has been developed in Germany is now ready for clinical testing. BTZ043, as the newly developed drug substance is called, is also effective against

Usutu virus decreases the population of common blackbirds in the outbreak region

The Usutu virus endangers birds and has been circulating in Germany since 2010. However, estimating its impact on bird populations in the outbreak region has hardly been possible up to now. For the

Fazenda Grande do Retiro: district in Salvador, Brazil

“The Brazilian Zika outbreak could end soon”

Scientists have elucidated the Zika burden in a Brazilian metropolis. Their data indicate: the outbreak may be coming to an end and further outbreaks in the region seem unlikely. The study has also

Pseudomonas aeruginosa: feared as a hospital germ

Molecular "Trojan horses" render infections visible

DZIF researchers at the Helmholtz Centre for Infection Research (HZI) develop new agents and methods for the localisation and treatment of multi-resistant bacteria. Molecular probes utilise the iron

SC83288 was effective in the late stages of malaria

Successful preclinical tests for new agent against severe malaria

Severe malaria, caused by the Plasmodium falciparum parasite, causes dangerous circulatory disorders and neurological complications. If the affected person is not treated immediately, the disease will

The picture shows the 76 different species included in the miBC collection, including 15 hitherto unknown taxa.

Microbiome: Mouse gut bacteria identified and archived

The communities of microbes in the intestine of the mouse, the gut microbiota, have a significant impact on the research output. However, there is still insufficient information available about many

MERS Corona virus particles outside the cell

MERS coronavirus: Vaccine candidate reveals efficacy in mouse model

Researchers of the Paul Ehrlich Institute (PEI) together with groups at the DZIF have developed a vaccine against MERS, that is highly immunogenic and indicates protection of vaccinated mice in

Ebola: the evolution of a dreaded virus

In the EU project “EVIDENT”, scientists investigated around 180 patient samples from the Ebola epidemic in West Africa, to elucidate the origin of the epidemic in the individual countries and the