Antibiotic resistance is a bacterial defense mechanism against antibiotics. It can rapidly spread from one bacterium to another. This makes antibiotics increasingly ineffective.
Detailed description
The level of resistances against antibiotics is rising. This is a great challenge for physicians and scientists. Scientists within the DZIF research field “Healthcare-associated and Antibiotic-resistant bacterial Infections” aim to develop new strategies against the development and spread of resistance.
According to the World Health Organisation (WHO), the global emergence of antibiotic resistance is one of the greatest threats to human health. In light of this, it is of utmost importance that new agents and target sites for drugs are identified. Once new lead compounds have been identified, the ...
Medicinal chemistry, also termed medical chemistry, researches chemical properties of new and old agents and develops innovative therapy options. Ralph Holl’s research group focuses on manufacturing and/or designing new inhibitors: small molecules that specifically target metabolic pathways in ...
United against infections The corona pandemic has made it clear how important infection research is. However, the emergence and spread of unknown viruses such as, most recently, SARS-CoV-2 is not new
Fighting the global spread of antibiotic-resistant bacteria and developing new antibiotics is an important goal at the German Center for infection Research (DZIF). In order to further accelerate
Many common antibiotics are increasingly losing their effectiveness against multi-resistant pathogens, which are becoming ever more prevalent. Bacteria use natural means to acquire mechanisms that
Tuberculosis treatment still entails the intake several antibiotics over a period of many months and is torturous for many patients. The pathogen’s increasing multidrug resistance additionally
In this project, the scientists develop genetically engineered phage lysins and specific bacteriocins for the elimination of hospital germs such as Staphylococcus aureus, they clarify mechanisms of potential resistance mechanisms, and they analyse whether broad-spectrum or specifically acting agents ...
The challenge of antibiotic drug development today is the discovery and optimisation of novel bioactive compounds that do not show cross-resistances with clinically applied antibiotics, ideally due to a novel mode of action (MoA) which adresses unexploited microbial targets. In the case of ...
Christoph Lange was recently appointed as Medical Director of the Research Center Borstel. From here, he substantially contributes to clinical tuberculosis research in Europe, also monitoring the
