Beta-lactamase | German Center for Infection Research

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Short description

Beta-lactamases are bacterial enzymes that can break down certain beta-lactam antibiotics, thereby rendering them ineffective.

Detailed description

Beta-lactamases break down the beta-lactam ring of certain beta-lactam antibiotics, which can confer antibiotic resistance to bacteria. Which antibiotics become ineffective depends on the specific beta-lactamase. Beta-lactam antibiotics include, among others, penicillins, cephalosporins, carbapenems, and monobactams. Some beta-lactamases, known as ESBLs (extended-spectrum beta-lactamases), can break down a broad range of penicillins and cephalosporins. Carbapenemases can also render carbapenems ineffective.

Beige coloured rapid antigen test with an opening for sample drops as well as a viewing window in which up to four green stripes become visible if one to four resistance factors are detected in the sample..

A rapid diagnostic test to detect multiple resistance determinants against the important carbapenem antibiotics

Every year at least 700,000 people die as a result of infection with antibiotic-resistant bacteria—a figure which according to WHO forecasts could rise to ten million people by 2050 without new

Feb 2023

Foodborne Pathog Dis

Prevalence, Characterization, and Antimicrobial Resistance of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli from Domestic Free-Range Poultry in Agogo, Ghana

Autoren

Akenten CW et al.

Oct 2017

Clin Infect Dis

Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum beta-Lactamase-Producing Enterobacteriaceae: Results From the INCREMENT Cohort

Autoren

Palacios-Baena ZR et al.

May 2022

Antibiotics (Basel)

Epidemiology of Plasmids in Escherichia coli and Klebsiella pneumoniae with Acquired Extended Spectrum Beta-Lactamase Genes Isolated from Chronic Wounds in Ghana

Autoren

Pankok F et al.

Feb 2016

Int J Antimicrob Agents

Detection of translocatable units in a blaCTX-M-15 extended-spectrum beta-lactamase-producing ST131 Escherichia coli isolate using a hybrid sequencing approach

Autoren

Ghosh H et al.

Nov 2015

J Clin Microbiol

Use of an Enrichment Broth Improves Detection of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae in Clinical Stool Samples

Autoren

Jazmati N

Hein R

Hamprecht A

Dec 2015

Vet Microbiol

Molecular characterisation of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates from hospital and ambulatory patients in Germany

Autoren

Pietsch M et al.

Feb 2014

Crit Rev Microbiol

Colonization and infection with extended spectrum beta-lactamase producing Enterobacteriaceae in high-risk patients - Review of the literature from a clinical perspective

Autoren

Biehl LM et al.

Oct 2021

Infect Dis Ther

Modelling and Simulation of the Effect of Targeted Decolonisation on Incidence of Extended-Spectrum Beta-Lactamase-Producing Enterobacterales Bloodstream Infections in Haematological Patients

Autoren

Döbele S et al.

Dec 2020

J Infect Dev Ctries

Molecular characterization of beta-lactamase genes produced by community-acquired uropathogenic Escherichia coli in Nouna

Autoren

Kiemde D et al.