CD4 T lymphocyte | German Center for Infection Research

Short description

CD4 T lymphocytes form a subgroup of T lymphocytes that is responsible for cell-mediated immune responses.

Synonyms

T helper cell

CD4 cells

Detailed description

T lymphocytes carrying the surface CD4 are called T helper cells. After activation, they release substances that are either involved in cell-mediated immunity or that stimulate B cell immune responses. infects mainly this T subgroup.

Researcher wearing a cap, mask, and lab coat pipetting at a sterile bench

Blood-based immunological signatures for extrapulmonary tuberculosis decoded

Tuberculosis (TB) is one of the world's leading infectious diseases. Infection with the bacterium Mycobacterium tuberculosis primarily affects the lungs, but in up to 25 percent of all infected

Two of the four winners of the Galenus von Pergamon Prize in the category of basic research—Dr. Alexander Simonis (center) and Prof. Dr. Florian Klein (second from right)—at the award ceremony. The Galenus Prize was presented by Professor Thomas Eschenhagen (second from left). The gala was hosted by Yve Fehring (left) and Matthias Gabriel (right). The individuals are standing next to each other on a stage in formal attire.

Research into alternatives to antibiotics wins Galenus von Pergamon Prize

In the future, antibodies against the virulence factors of Pseudomonas aeruginosa may serve as an alternative to antibiotics. DZIF scientists at University Hospital Cologne have been awarded the 2025

Structural representation of the binding of antibody 04_A06 to the HIV-1 surface protein

Antibody discovered that blocks almost all known HIV variants in neutralization assays

An international research team led by scientists from the DZIF at the University of Cologne has discovered an antibody that neutralizes the human immunodeficiency virus HIV-1 in almost all tested

Prof. Stephan Urban in the laboratory; the Chris McGuigan Prize trophy is added to the left of the picture.

Chris McGuigan Drug Discovery Award for Heidelberg virologist Stephan Urban

On September 18, Prof. Dr. Dr. h.c. Stephan Urban, DZIF Professor of Translational Virology at Heidelberg University's Medical Faculty, was honored with the McGuigan Award for Distinguished Work in

A scanning electron microscope image showing a single red-stained T cell infected by numerous mustard-colored HIV particles adhering to its surface.

How HIV enters the genome – Researchers identify previously unknown mechanism

Researchers at the German Center for Infection Research (DZIF) at Heidelberg University Hospital have decoded a previously unknown mechanism by which HIV-1 selects its integration targets in the human

Apr 2025

Nat Commun

IL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue

Autoren

Kaiser KM et al.

Mar 2025

Exp Hematol Oncol

All-in-one CRISPR/Cas-engineered glucocorticoid-receptor knock-out EBV-gp350-CAR knock-in T cells are potent and resistant to dexamethasone

Autoren

Kaeuferle T et al.

Apr 2025

JCI Insight

Early treatment and PD1 inhibition enhance HIV-specific functionality of follicular CD8+ T cells

Autoren

Rueger S et al.

Mar 2025

Cancer Commun

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Autoren

Järke L et al.

University Hospital Cologne

PANTIPA—Preclinical development of patient-derived monoclonal antibodies targeting Pseudomonas aeruginosa

Pseudomonas aeruginosa is a multidrug-resistant bacterium that can cause life-threatening infections, such as sepsis and pneumonia. One of the key weapons used by this bacterium is the type III secretion system (T3SS), which contains the protein PcrV. Researchers at the DZIF discovered that patients ...