Dysbiosis | German Center for Infection Research

Short description

Dysbiosis refers to an imbalance in the microbial ecosystem in which harmful microorganisms predominate and adversely affect the host's health.

Synonyms

dysbiotic

Detailed description

Dysbiosis (from Greek dys = bad/abnormal and bios = life) describes the disruption of the physiological state of the microbiome (e.g., on the skin, in the gut, or in the mouth), where an imbalance in microbial colonization causes the overgrowth of pathogens and suppression of beneficial microorganisms, negatively impacting the health of the host. Among others, Dysbiosis can lead to chronic inflammation, autoimmune diseases, and severe infections. Dysbiosis is the opposite of eubiosis.

Aug 2024

NPJ Biofilms Microbiomes

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Autoren

Essex M et al.

Helmholtz Centre for Infection Research

Uncovering the interplay between gut microbiota and the immune system in cirrhotic patients (TIPINF)

Bacterial infections are one of the most severe complications in patients with decompensated liver cirrhosis. The immune system of this patient group is weakened due to a complex dysfunction of the immune system (cirrhosis-associated immune dysfunction, CAID). The cause of the immune system ...

Jan 2024

Ann Surg

Microbiome Dysbiosis with Enterococcus Presence in the Upper Gastrointestinal Tract is A Risk Factor for Mortality in Patients Undergoing Surgery for Pancreatic Cancer

Autoren

Stein-Thoeringer CK et al.

Bonn - Köln

Pathogenic ecophysiology

The working group "Pathogenic ecophysiology" investigates the adaptations of resistant, enteropathogenic bacteria (such as vancomycin-resistant enterococci) to the conditions inside the human gut microbiome. The researchers analyze how interactions between bacteria and the host, as well as the shift ...

Jul 2016

J Neurosci