HCV | German Center for Infection Research

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Short description

The C virus (HCV) causes inflammation of the liver.

Synonyms

Hepatitis C virus

Detailed description

The RNA virus infects human liver cells. Due to its high mutation rate, a lot of genetic variations exist. The WHO estimates that one percent of the world population is chronically infected with HCV. Transmission is mainly via contaminated blood and can happen in hospitals or through drug use. HCV infection can lead to liver cell carcinoma.

Schematic representation of the molecular blockade of the NTCP receptor by bulevirtide

Mechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered

Over 12 million people worldwide suffer from a chronic infection with the hepatitis D virus. This most severe viral liver disease is associated with a high risk of dying from liver cirrhosis and liver

Mar 2024

Nat Commun

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

Autoren

Liu H et al.

ANRS | MIE

The French National Research Agency for HIV, viral hepatitis and emerging infectious diseases (ANRS | MIE) is mandated to…

Impfstoffentwicklung

Therapeutic Vaccine for Chronic Hepatitis B Enters Clinical Trial

TherVacB, a novel therapeutic vaccine to combat chronic hepatitis B, entered the first clinical trial. The vaccine was designed and developed under the leadership of Helmholtz Munich. This phase Ia

Ehrendoktorwürde Prof. Urban

Outstanding hepatitis research: DZIF Professor receives honorary doctorate

The Faculty of Medicine at the University of Basel has awarded an honorary doctorate to DZIF Professor Dr Stephan Urban from the Medical Faculty at the Heidelberg University. The award acknowledges

DZIF Executive Board member Prof. Maura Dandri, DZIF managing director Dr Timo Jäger and ANRS | MIE Director Prof. Yazdan Yazdanpanah at the signing ceremony of the MoU at ANRS | MIE in Paris. Standing in the background are Roll-ups of ANRS | MIE and DZIF.

Collaboration of the DZIF and the French ANRS | MIE to advance research in infectious diseases

The German Center for Infection Research (DZIF) and the French National Research Agency for HIV, viral hepatitis and emerging infectious diseases (ANRS | MIE) announced their commitment to

Jul 2023

Antiviral Res

Janus kinase-inhibition modulates hepatitis E virus infection

Autoren

Kinast V et al.

Jul 2023

Eur J Immunol

Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct-acting antivirals

Autoren

Bi W et al.

Jul 2023

PLoS Pathog

Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

Autoren

Pham MT et al.

Aug 2023

Emerg Microbes Infect

Enhanced Monitoring and Detection of Recent Genotype 3 Hepatitis E Virus Infection through Urine Antigen Testing

Autoren

Stahl Y et al.