A natural compound is a substance produced by bacteria, animals, fungi or plants that fulfills a biological function.
Detailed description
A large part of the currently used active substances is derived from natural compounds, which have been optimized by scientists for their application in humans. They fulfill a special function in the producing organisms like for example the defense against predators. Using high-throughput methods, scientists screen different organisms and use the identified substances to compile substance libraries, which can then be searched for specific functions.
According to the World Health Organization (WHO), tuberculosis (TB) affects more than 10 million people and causes over a million deaths each year, making it one of the world’s deadliest infectious
When the bacterial pathogen Pseudomonas aeruginosa infects the body, it uses the sugar-binding protein LecA to attach itself to human cells, invade them, and form so-called biofilms. LecA thus plays a
The German Research Foundation (DFG) and the French Agence National de la Recherche (ANR) are now funding the project "Characterization of novel natural product binding sites in the DNA gyrase of
Antibacterial drugs are important for treating infections. However, increasing bacterial resistance to current drugs—making them ineffective or only partially effective—means that new drugs are
Antimicrobial resistance (AMR) is one of the most urgent challenges facing global health and development. Described as a “creeping pandemic” by the G7 forum of leading economic nations, AMR occurs
Professors Ivo Boneca (Institut Pasteur, Paris), Mark Brönstrup (Helmholtz Centre for Infection Research, Braunschweig, and German Center for Infection Research), and Christophe Zimmer (University of
Most antibiotics used in human medicine originate from natural products derived from bacteria and other microbes. Novel microorganisms are therefore a promising source of new active compounds—also for
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Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment. Researchers at the University Hospital Bonn (UKB), the University of Bonn and
