cccDNA
cccDNA (covalently closed circular DNA) is a particularly stable, circular DNA structure found in certain viruses. In hepatitis B virus infections, it plays an important role in the long-term persistence of the infection.
Detailed description
cccDNA is found in hepadnaviruses, among others, including the hepatitis B virus (HBV). During an HBV infection, it forms in the nucleus of infected liver cells and serves as a template for the production of viral RNA and thus for viral replication. Because cccDNA can persist in infected cells for long periods, it forms an important reservoir of viral genetic material. It plays a major role in allowing hepatitis B infection to persist despite antiviral treatment. Researchers are therefore developing new therapeutic approaches to permanently silence cccDNA or specifically eliminate it.
