Immunodeficiency manifests in a reduced resistance to infections and, as a consequence, in an increased susceptibility to disease.
Synonyms
Immunodeficiency disease
Detailed description
Immunodeficiency can have genetic causes or manifest as a consequence of certain diseases such as HIV infections, cancer and gut diseases. It may even be induced artificially before bone marrow transplantations. The weakened immune system makes patients more susceptible to usually harmless pathogens. Persons suffering from immunodeficiencies profit a lot from vaccines and immunotherapies.
The Clinical Research Unit (CRU) at Tübingen University Hospital, headed by Christoph Stein-Thoeringer, combines expertise from the fields of clinical medicine, infectious diseases, microbiome research, immunology, basic sciences, and epidemiology. Scientists and physicians collaborate closely to ...
When emerging viruses cause severe diseases, the rapid development of vaccines and antivirals against these pathogens becomes critical. Some newly emerging viruses are very dangerous and necessitate the highest of biosafety levels for research and development purposes. DZIF scientists have a ...
Mosquitoes are transmitters of numerous viruses that are pathogenic to humans. Besides the known local species, new types of mosquitoes have been imported into Germany over the past few years. In order to prepare for the potential formation of colonies of these new types of mosquitoes and the ...
Professor Markus Cornberg is Clinical Director of the Helmholtz Centre for Infection Research (HZI) and Co-Director of the Centre for Individualised Infection Medicine (CiiM). He and his translational research group provide the necessary link between hospitals, the HZI, the HepNet Study-House trial ...
The research group “Mathematical models and biostatistics” supports scientists in the field of malaria research with bioinformatics methods. Their aim is to more accurately determine the courses of infection, the spread of pathogens and human immune responses. In addition, their studies provide data ...
The Clinical Trials Platform at the Tübingen Institute of Tropical Medicine supports the development of new agents and vaccines against infectious diseases. It focuses on conducting experimental studies and first trials on humans. A special feature is the human malaria infection model, developed in ...
The CERMEL (Centre de Recherche Médical de Lambaréné) in Gabon is one of the leading establishments for malaria research in Africa. Clinical trials on vaccines and agents are tested according to the same approved guidelines that are used in Germany. A clinical research group was established within ...
The imaging platform in Heidelberg offers scientists the most up-to-date microscopes and imaging techniques. It enables the observation of pathogenic processes both in complex tissues and in vivo. This platform was designed to accommodate biosafety levels BSL 2 and 3, both of which are important for ...
All 35 DZIF partner institutions are members of DZIF e. V. (eingetragener Verein, registered association) under German law. According to German law, the General Assembly (GA) and the Executive Board
