Last-resort antibiotic

Short description

Last-resort antibiotics are antibiotics whose use should be reserved for specific situations, such as severe infections caused by resistant bacteria.

Synonyms

Reserve antibiotic

Antibiotic of last resort

Detailed description

Particularly, last-resort antibiotics are used when other suitable antibiotics are not an option due to resistance or other medical reasons. Which antibiotics are considered a last resort may depend on the specific pathogen, the infection, and current treatment guidelines. Their targeted and judicious use is intended to help preserve their effectiveness and limit the further spread of antibiotic resistance. Among other factors, the selection of an appropriate antibiotic depends on the pathogen, its resistance profile, the site of infection, and the patient’s health status.

Oct 2025

Adv Sci (Weinh)

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Autoren

Srinivasan D et al.

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If an intestinal inhabitant such as the bacterium Escherichia coli (E. coli) becomes resistant to many antibiotics, it can cause serious health problems if it enters the bloodstream. How can such

13 Nov 2025

Workshop

Federal Institute for Drugs and Medical Devices (BfArM)
Kurt-Georg-Kiesinger-Allee 3
53175 Bonn
Germany

public

Angew Chem Int Ed Engl

A Targeted Click-to-Release Activation of the Last-Resort Antibiotic Colistin Reduces its Renal Cell Toxicity

Autoren

Charoenpattarapreeda J et al.

Detailed description

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