A resistance gene contains the information for the production of a protein that makes an antibiotic ineffective and hence confers resistance against an antibiotic to a pathogen.
Detailed description
Resistance genes are usually found on a ring-shaped piece of DNA, the plasmid. Like this, they can easily be passed on from one bacterium to another. Plants can possess resistance genes as well. They are usually directed against herbicides and pests.
In this project, the scientists develop genetically engineered phage lysins and specific bacteriocins for the elimination of hospital germs such as Staphylococcus aureus, they clarify mechanisms of potential resistance mechanisms, and they analyse whether broad-spectrum or specifically acting agents ...
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
The challenge of antibiotic drug development today is the discovery and optimisation of novel bioactive compounds that do not show cross-resistances with clinically applied antibiotics, ideally due to a novel mode of action (MoA) which adresses unexploited microbial targets. In the case of ...
Christoph Lange was recently appointed as Medical Director of the Research Center Borstel. From here, he substantially contributes to clinical tuberculosis research in Europe, also monitoring the
Jörg Janne Vehreschild started his professional career as a programmer. However, he soon decided to pursue his second passion and began his medical studies a year later. Today, at only 39, Vehreschild
In the journal The Lancet, DZIF researchers from the Research Center Borstel and their colleagues from England and South Africa make the case for optimising tuberculosis drug development. They
For the population geneticist Ulrich Nübel almost everything revolves around gene sequences of bacterial strains. The scientist obtains a lot of information through analysing them: The course of
The hepatitis C research success story is also his story: Ralf Bartenschlager, a virologist at the Heidelberg Medical Faculty of Heidelberg University, has been researching the hepatitis C virus for
The German Federal Ministry of Education and Research is joining forces with international partners in a new initiative to promote research into antimicrobial resistance (AMR). The aim is to fight
Early detection of antibiotic resistant pathogens can be life-saving. DZIF-scientists at the Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, have developed an
