Virulence | German Center for Infection Research

Short description

Virulence is a ’s ability to cause disease. It determines the degree of pathogenicity.

Detailed description

Virulence is determined through virulence factors of the , which help the pathogen to spread within the infected host.

Scanning electron micrograph of a human macrophage in black and white

Reckoned without the host: The transmission of tuberculosis depends on more than just the pathogen

Different groups of TB bacteria exist worldwide with different regional distribution: some are generalists and can be found on many continents, while others are very limited in their spread. An

The INCATE team at the AMR conference in Basel 2024

INCATE receives Lighthouse Award 2024 from Swiss National Science Foundation

INCATE, the INCubator for Antimicrobial Therapies in Europe co-founded by the German Center for Infection Research, has been honoured with the 2024 Lighthouse Award for outstanding Transfer of

Dec 2023

Microbiol Spectr

Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli

Autoren

Deschner F et al.

Feb 2023

Commun Biol

Genome-scale model of Pseudomonas aeruginosa metabolism unveils virulence and drug potentiation

Autoren

Dahal S et al.

Oct 2023

J Biol Chem

HilE represses the activity of the Salmonella virulence regulator HilD via a mechanism distinct from that of intestinal long-chain fatty acids

Autoren

Joiner JD et al.

Red-coloured rod-shaped bacteria in an electron micrograph.

Treating tuberculosis when antibiotics no longer work

Tuberculosis is currently the infectious disease that causes the most deaths worldwide. Of particular concern is the increasing emergence of multidrug-resistant tuberculosis bacteria, particularly in

Aug 2023

Nat Commun

mRNA 3'UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Autoren

Bergant V et al.

Cryo-electron microscopic reconstruction of molecular structures: On the left, the vertical representation of the binding of a yellow-coloured antibody to the blue-coloured tip of the secretion system shown in grey. On the right, a top view of the binding structure, showing how the yellow antibody binds laterally to the blue tip of the secretion system, which is round in top view.

Neutralising antibodies that target resistant bacteria

Antibiotic-resistant bacteria pose a major challenge to healthcare systems worldwide. Due to numerous resistance mechanisms, infections with the pathogen Pseudomonas aeruginosa are particularly feared

Jun 2023

Microbiology

Virulence-associated type III secretion systems in Gram-negative bacteria

Autoren

Pais SV

Kim E

Wagner S

Jun 2023

PLoS Pathog

The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections

Autoren

Wichers-Misterek JS et al.