ESBL
Short description
ESBLs (extended-spectrum beta-lactamases) are bacterial enzymes that can break down certain beta-lactam antibiotics, thereby rendering them ineffective.
Synonyms
Beta-Laktamasen mit erweitertem Spektrum
Detailed description
ESBLs are beta-lactamases with an extended spectrum of activity. They can break down various beta-lactam antibiotics, particularly many penicillins and cephalosporins, thereby conferring resistance to these antibiotics on the bacteria that produce them. ESBLs are particularly common in enterobacteria such as Escherichia coli and Klebsiella pneumoniae. The genes for ESBLs can be transferred between bacteria. ESBL-producing bacteria often exhibit additional antibiotic resistances, which can complicate the treatment of infections.