Multidrug resistance | German Center for Infection Research

Short description

Multidrug resistance means that bacteria or viruses are insensitive towards various antibiotics or antivirals, respectively.

Synonyms

Multiple drug resistance

Detailed description

There is a general increase of resistances against antibiotics. Infections with multidrug-resistant pathogens pose a serious problem as their treatment with antibiotics is difficult or not possible any more.

The picture shows a scientist examining a Petri dish containing a bacterial culture. The person is in a laboratory; other laboratory equipment and sample containers can be seen in the background.

Thinking beyond antibiotics in the treatment of urinary tract infections

A research team from Switzerland and Germany has explored the combined use of phage and fecal microbiota transplantation to treat female patients with recurrent urinary tract infections that do not

Black-and-white electron micrograph of a rod-shaped, dark gray bacterial cell surrounded by a thick layer of light gray filaments.

From urinary tract infection to brain abscess: How bacterial subpopulations can spread to distant body sites

Researchers from the University of Cologne, the German Center for Infection Research (DZIF), and the Broad Institute of Harvard and MIT present a remarkable clinical case in the New England Journal of

Universität zu Lübeck

R-Net SHIELD: Surveillance of healthcare data to identify and evaluate risk factors for predicting long-term colonization and infection with MDRO

The previous R-Net projects (R-Net 1.0 and 2.0) provided important insights into the prevalence of multidrug-resistant organisms (MDROs) through cross-sectional studies. However, the longitudinal development of colonization and the factors influencing its acquisition, persistence, and transmission ...

Red-coloured rod-shaped bacteria in an electron micrograph.

New genomic test reveals hidden drug-resistant tuberculosis in Eswatini

Researchers in Eswatini, in collaboration with an international consortium, have made a significant breakthrough in tuberculosis (TB) diagnostics. Using targeted genome sequencing, they detected drug

Treatment of a patient during the clinical study of SPAP in Gabon

Promising single-dose malaria treatment advances toward pan-African clinical trial

Researchers at the German Center for Infection Research (DZIF) have developed a promising single-dose malaria treatment that could help address growing drug resistance and simplify treatment for

Dec 2025

Biochim Biophys Acta Gen Subj

Tetrahydroquinoline/4,5-dihydroisoxazoline derivatives counteract multidrug resistance in cancer cells by inhibiting P-glycoprotein (ABCB1)-mediated transport

Autoren

Hembecker M et al.

University Hospital Tübingen

TIARA-IMPACT: Immunological and microbiome-based predictors of postoperative infections

Postoperative infections following major abdominal surgery remain common and difficult to predict. A key reason is the incomplete understanding of how individual differences in the gut microbiome, host immunity, and microbial metabolites shape infection susceptibility. Following completion of ...

Processing of sputum samples for the culture of Mycobacterium tuberculosis and drug-resistance testing in the tuberculosis lab in Riga.

Long-term cure rates for multidrug-resistant tuberculosis much better than expected

A new national cohort study from Latvia, conducted in collaboration with researchers from the clinical tuberculosis infrastructure (ClinTB) of the German Center for Infection Research (DZIF) at the

The GUARDIAN project uses AI to combat antibiotic-resistant bacteria.

Kickoff meeting for the GUARDIAN research project in Giessen marks the launch of interdisciplinary collaboration against antibiotic resistance

At the DZIF partner site in Giessen, a ceremonial kickoff meeting marked the launch of the GUARDIAN research project, which is funded with 3.5 million euros by the Federal Ministry of Research

The photo shows a woman wearing a mask receiving a vaccination in her arm from a person wearing blue gloves. The DZIF and Ethris logos can be seen in the corners of the image.

Ethris and German Center for Infection Research (DZIF) announce strategic collaboration to develop mRNA-based vaccines

Ethris GmbH, a clinical-stage biotechnology company pioneering next-generation RNA therapeutics and vaccines, and the German Center for Infection Research (DZIF), today announced a strategic research