Biobanks store biological samples such as human tissue, blood and DNA. These samples and the corresponding medical data are of particular value for translational research at the DZIF. They can be used to uncover disease causes in infection research and develop new preventive, diagnostic and therapeutic methods.
Basic prerequisites for the use of modern analysis methods (e.g. Omics technologies) and the generation of reproducible research results are always the professional and quality-assured retrieval, processing and storage of liquid sample material and tissue.
Biobanking at the DZIF sites is coordinated and supported by the infrastructure "Biobanking"..
The infrastructure supports the collection of human biomaterials at the DZIF. It functions as a central point of contact and as an open support and technology platform. With locations in Heidelberg (coordination and tissue) and Munich (liquid biomaterials, ZBR), the infrastructure´ biobanking experts support all DZIF researchers with tailored advice and assistance.
The infrastructure supports and advises scientists on sample collection and processing and offers state-of-the-art processing and analysis methods with a technology platform.
- Establishment and provision of standard operating procedures (SOPs) for all biobank-related topics, such as sample collection, processing, storage, transport, etc.
- Conducting and advising on internal audits to review one's own processes, especially in multicentre studies
- Provision of audit training for a facility’s own QM personnel
- Central Biosample Registry (DZIF-ZBR)
- Biobanking catalogue
- Development of individual logistics concepts for biomaterial collection, processing, documentation, and storage. Assistance in the planning of projects involving collection of human biomaterials including cost calculation.
- Advice on the design of customised storage solutions as well as the selection and implementation of IT solutions for human biomaterial collections.
- Individual advice on ethical and legal issues related to human biomaterial collections, such as patient information, informed consent forms and ethical votes.
- Provision of a generic ethics and data protection concept including patient information (master text) for DZIF projects with human biomaterial collection upon request.
- Frequent workshops and training sessions for DZIF employees on all relevant biobanking topics, such as pre-analytics, storage systems or planning of biomaterial collections.
- DZIF-internal lectures and presentations on all biobanking topics upon request.
- Information material on infrastructure services.
State-of-the-art technologies for the derivate generation and analysis of solid and liquid human biomaterials. For tissue samples, the DZIF tissue bank offers nucleic acid extraction, immunohistochemical staining and the creation of tissue microarrays. In addition to nucleic acid extractions, metabolome analyses and sequencing may be offered for liquid biomaterials for a fee.
Central biosample registry
In order to utilise the biomaterials from the individual decentralised DZIF storage locations for research purposes, the infrastructure "Biobanking" at the Helmholtz Zentrum München conducts the Central Biosample Registry (DZIF-ZBR). The ZBR merges the biomaterial data from the local systems and consolidates the data from the various sites and studies, making it a valuable data harmonisation tool. By providing the DZIF scientists an overview of the collected biomaterials and associated data via individual search queries, the ZBR thus offers an effective instrument for project planning using biomaterials.
This is how you gain access to the data in the ZBR
The DZIF biobanking catalogue lists the biobanks and sample collections available at the various individual locations with reference to the DZIF. A brief outline of the individual collections can be found under ‘participating biobanks’. Here you will find information about the biobanks and sample collections of human biomaterials currently available within the DZIF as well as about biobanks of DZIF partners. A brief description of the individual biobanks can be found under the respective acronyms.
More detailed information on the biobanks can be found in the
Access to the biobanking catalogue is password restricted. If you do not have personal access, you can also log in as a ‘guest’.
DZIF tissue bank
The central DZIF tissue bank at the Heidelberg location provides collectives of relevant tissue samples for research projects at the DZIF. The tissue bank also offers state-of-the-art tissue analysis and technology.
Tissue samples and related services can be requested from the DZIF tissue bank using the following forms: