Gastrointestinal Infections

A sequencing platform will be made available as part of this research unit, whose focus is translational microbiome research. The know-how for sequencing and bioinformatic data analysis is used in various preclinical and clinical trials at the DZIF. One example is the so-called SPEKTRUM study, which is investigating the influence [...]

The intestinal microbiome plays a crucial role in the course of infections. As part of this research platform, Prof. Bärbel Stecher and her team are examining what exactly happens when gram-negative pathogens and opportunists colonise the intestine. An important project is targeting enterohaemorrhagic E. coli (EHEC) bacteria, which can trigger [...]

The know-how for microbiome analysis coalesces at the Centre for GI Microbiome Research (CEGIMIR). The gastrointestinal microbiome, i.e. all the microorganisms in the gastrointestinal tract, plays a key role in the course of infections. Changes in composition, such as those caused by environmental factors or diseases, may, among other things [...]

CEGICLIN is a virtual centre for gastrointestinal clinical trials. Study nurses from this centre are available to the three DZIF Partner Sites involved in this area of research. The Centre also collaborates closely with the DZIF’s clinical trial units and regional clinical trial centres. This enables more flexible provision of [...]

Guntram Graßl and his team study interactions between microbiomes and human hosts, as well as between microbiomes and bacterial pathogens in the gut. Scientists assume that certain bacteria or groups of bacteria protect the gut from pathogens by ensuring that Salmonella or Clostridioides difficile, for example, do not colonise [...]