A resistance gene contains the information for the production of a protein that makes an antibiotic ineffective and hence confers resistance against an antibiotic to a pathogen.
Detailed description
Resistance genes are usually found on a ring-shaped piece of DNA, the plasmid. Like this, they can easily be passed on from one bacterium to another. Plants can possess resistance genes as well. They are usually directed against herbicides and pests.
The antibiotic Bedaquiline (BDQ) was approved in 2014 specifically for the treatment of multidrug-resistant (MDR) tuberculosis (TB) and has since been an important component of successful MDR TB
Prof. Ernst's working group operates at the interface of molecular microbiology, genomics, epidemiology and chemical biology to identify, investigate, and target unrecognized pathways in persistent and multidrug-resistant infections. To this end, the group conducts mechanistic investigations ...
The bacterial pathogens Chlamydia trachomatis and Neisseria gonorrhoeae are the most common sexually transmitted infections (STIs) leading to infertility in women. The World Health Organisation (WHO) estimates that 89 million new infections with genital chlamydia and 78 million infections with ...
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Effective drugs against viral diseases like COVID-19 are urgently needed now and in the future. The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. The DZIF
How can the results of molecular resistance tests be used to optimize drug therapy for tuberculosis? An international panel of experts has updated a consensus document outlining how to interpret
Bacteria of the genus Enterobacter are among the most dangerous bacteria associated with hospital infections worldwide. Some of their representatives are highly resistant to commonly used antibiotics
Helicobacter pylori is one of the top 10 bacterial threats listed by the WHO, for which treatment is becoming increasingly difficult due to rising antibiotic resistance. More than half of the world's population is chronically infected with this bacterium. H. pylori is a recognised class I carcinogen ...
