Working group

Computational systems biology of infections and antimicrobial-resistant pathogens

Short description

Andreas Dräger's research group is dedicated to computational systems biology with a focus on infections and antibiotic-resistant pathogens. A primary goal is deriving model-driven new hypotheses with which increasing antibiotic resistance can be systematically combated. The group, which is based at the Institute of Biomedical Informatics at the University of Tübingen, works closely with partners from the nearby Institute of Microbiology and Infection Medicine. Their goal is to systematically elucidate the molecular processes in the human nose through which many bacteria enter the body. Which organisms are present in this microbiome, and how do they influence each other? The group's work includes the reconstruction of biological systems, their mathematical modeling, the standardization of these models, the development of specialized software solutions, and the application of machine learning methods.

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The members of the working group (from left to right) (as of 2022): Anna Lefarova, Fatma Ece Altınışık Kaya, Dr Reihaneh Mostolizadeh, Nantia Leonidou, Jun.-Prof. Dr Andreas Dräger, Gwendolyn O. Gusak, Carolin Brune, Famke Bäuerle.


The scientists are developing large-scale computer models of known nasal bacteria and are working on specific software solutions for their simulation and analysis. In addition, the working group participates in international standardization projects for the unified representation of computer models and promotes new methods of visualizing large systems.


© Eberhard Karls Universität Tübingen/Systembiologie-Gruppe

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