Working Groups

Proteins form different conformations in combination with other proteins—as multimers or heterocomplexes—than when they are present as monomers. Static descriptions of protein structures are therefore often not sufficient to describe their dynamic properties. Nevertheless, current simulations of ...

The majority of successful antibiotics are derived from microorganisms and the potential of finding new agents in this group is yet to be exploited. Using genome sequencing, scientists have frequently discovered gene clusters with potential antibiotic activity. However, synthesis does not occur ...

As part of a partnership, the Eastern European Study Site (EESS) was established in Bucharest, Romania, in collaboration with the Marius Nasta Institute and its affiliated tuberculosis hospital. Eastern European countries have a high incidence of tuberculosis, especially of the multidrug-resistant ...

The "Evidence-based medicine (EBM) in tropical medicine" working group strengthens evidence-based tropical medicine within the DZIF by collating and critically evaluating scientific evidence on the diagnosis, treatment, and prevention of tropical infectious diseases such as malaria or dengue ...

Professor Marc Stadler’s research group examines cultures of rare types of fungi and bacteria, predominantly from tropical regions, for their potential to develop new antibiotic substances. Thanks to international partnerships, these substances are isolated, identified and subsequently transferred ...

Ulrich Nübel’s group investigates the biosynthetic potential of myxobacteria and other groups of bacteria by means of genome analysis. State-of the art sequencing methods and comprehensive calculation capacities are available for this purpose at the Leibniz Institute DSMZ. The group has already ...

The FUNMIC platform (Functional Microbiome Research at Interfaces) investigates the role of the human microbiome in infectious diseases and how its functions can be harnessed for new approaches to diagnosing, preventing, and treating infections. The focus is on microbial communities in the ...

The HepNet Study-House connects individual study centers in the field of hepatitis research and creates a central platform to conduct clinical studies (Investigator Initiated Trials) and build patient cohorts in the field of viral hepatitis. On the one hand, the Study-House is a contact point for ...

Prof. Ernst's working group operates at the interface of molecular microbiology, genomics, epidemiology and chemical biology to identify, investigate, and target unrecognized pathways in persistent and multidrug-resistant infections. To this end, the group conducts mechanistic investigations ...

Humanized mice carrying human genes or cells, for example, are a crucial model for disease research and drug development. Generating them and keeping them in optimal conditions requires a lot of know-how and experience. Therefore, a professional central unit with humanized mice (Humanized Mouse Core ...