Experts at the Bonn - Köln partner site focus on combating viral and bacterial infectious diseases. In the area Novel Antibiotics, the preclinical development of the new antibiotic Corallopyronin A is being advanced in cooperation with the Translational Project Management Office (TPMO) and the Federal Institute for Drugs and Medical Devices (BfArM). Vaccines against bacterial pathogens such as S. aureus and A. baumannii as well as activities on neglected tropical diseases are further focal points. In the area Healthcare-associated and Antibiotic-resistant bacterial Infections, the focus is on therapies for infections with multidrug-resistant pathogens as well as infection control measures. The development of nucleic acid-based adjuvants, analysis of mechanisms of action of mRNA vaccines and targeted activation of innate antiviral immunity make important contributions to the area Infections of the Immunocompromised Host. In HIV research, T cell-mediated immunity is being explored and antibody-mediated therapeutic approaches are being taken into translation. Other foci include SARS-CoV-2 research and the newly established VACCELERATE clinical research network.